At the 8-cell stage of mouse embryo development, the coordination between DNA unwinding and replication appears to improve. © ...

随后研究团队研究发现抑制RF-RDs会导致复制叉新生DNA的降解，并显著增加DNA末端切割和DNA断裂的发生。进一步体外生化实验和细胞实验表明，RF-RDs能够抑制核酸酶DNA2的核酸酶活性，从而减缓DNA2对复制叉的降解。研究团队进一步通过全基因组 ...

Mutational signatures etched into the cells' genome by an anti-cancer drug called temozolomide (TMZ) uncover an Achilles' heel for TMZ chemotherapy resistance, according to new research.

In spite of intensive research, glioblastoma remains one of the most lethal types of brain cancer. Temozolomide (TMZ) is used as the front-line medicine in its treatment.

In spite of intensive research, glioblastoma remains one of the most lethal types of brain cancer. Temozolomide (TMZ) is used ...

As there are currently no treatments for BKPyV, infection can cause graft loss. With only seven genes, BKPyV relies on its ...

Phase 1/2 study initiated for ATX-559, a first-in-class inhibitor of DHX9, focused on patients with BRCA1/2-deficient breast cancer and MSI-H and/or dMMR ...

CNET's experts have pitted the best DNA testing kits against each other to help you pick the right one for your needs. Shelby Brown Editor II Shelby Brown (she/her/hers) is an editor for CNET's ...

BK polyomavirus, or BKPyV, is a major cause of kidney transplant failure. There are no effective drugs to treat BKPyV.

BK polyomavirus, or BKPyV, is a major cause of kidney transplant failure. There are no effective drugs to treat BKPyV. Research at the University of Alabama at Birmingham reveals new aspects of BKPyV ...

The study is published in the journal PLOS Pathogens. With only seven genes, the BK polyomavirus must use the host cell’s DNA replication machinery to produce new viruses. Although the virus was ...