Prevention of drug-resistant tuberculosis is a global health priority. However, trials evaluating the effectiveness of treating Mycobacterium tuberculosis infection among contacts of persons with ...

Worldwide, approximately 2 million children younger than 15 years of age are infected with multidrug-resistant (MDR) Mycobacterium tuberculosis, with MDR tuberculosis developing in approximately ...

From August 8, 2018, to January 14, 2020, we vaccinated 265,183 participants. Of these vaccinees, 102,515 were monitored on days 0, 3, and 21 for safety. Among the contacts and contacts-of ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

The Race and Medicine collection reflects NEJM’s commitment to understanding and combating racism as a public health and human rights crisis. Our commitment to antiracism includes efforts to ...

Dr. James Q. Zhou (Medicine): A 56-year-old woman with metabolic dysfunction–associated steatohepatitis and cirrhosis was admitted to this hospital because of end-stage liver disease. The ...

Welcome and thank you for considering the New England Journal of Medicine (NEJM) as a venue for your work. As the oldest continuously-published medical journal, our mission since 1812 has been to ...

Dr. Vandana L. Madhavan: A 30-month-old boy was admitted to this hospital for the third time in 4 weeks because of recurrent fever. The patient had been well until 4 weeks before the current ...

Chronic venous insufficiency arises from a complex interplay of genetic predisposition; environmental factors, such as jobs that require prolonged standing or carrying heavy loads; and age-related ...

Standard treatment for multibacillary leprosy is multidrug therapy consisting of dapsone, rifampicin, and clofazimine, with a recommended treatment duration of 12 months. 4 Challenges include ...

Nivolumab, a PD-1 inhibitor, and ipilimumab, a cytotoxic T-lymphocyte antigen 4 inhibitor, are immune checkpoint inhibitors with complementary mechanisms of action, which might enhance antitumor ...

The Sepsis-1, Sepsis-2, and Sepsis-3 definitions are for adult sepsis. The IPCC (International Pediatric Sepsis Consensus Conference) and Phoenix definitions are for pediatric sepsis. ARDS denotes ...