Dulcolax suppositories generally work in about 20 ... If you are about to be started on any new medicine, remind your doctor and pharmacist that you are using Dulcolax. Drink plenty of water ...

The pharmacokinetics of promethazine administered in oral syrup and rectal suppositories were highly variable, but, in general, the suppositories produced a lower C max and later t max than the syrup.

Bioavailability for each suppository treatment relative to the syrup is shown in Figure 4. Mean bioavailability relative to the syrup was 70%, 97%, and 84% for the two 12.5-mg suppositories ...