Toggling in the spliceosome John Abelson Nature Structural & Molecular Biology (2013) A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation ...

Is this a glimpse of the spliceosome's catalytic core? Identifying divalent metal ion binding sites in RNA molecules is a formidable task, especially when the RNAs reside within large, dynamic ...

During splicing, this transcript undergoes modification: a cellular editing complex, the spliceosome, removes certain segments. The outcome varies depending on which parts are cut out, resulting ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

We study regulation of gene expression by the minor spliceosome. This parallel pre-mRNA splicing machinery functions during the nuclear RNA processing phase and regulates cellular mRNA levels. We ...

USP39 stabilizes the spliceosome (green), which cuts out unneeded parts (grey and purple) of the mRNA. If USP39 is missing, some of the mRNA is poorly processed. This results in misfolded proteins ...